Nitroxynil

What does it treat?

√ Liver fluke √ Roundworm

• Nitroxynil is still registered for subcutaneous use in cattle in Australia, but is not currently available as a sole active. Nitroxynil is currently only available in Australia as a mixture with clorsulon, or a combination and mixture with clorsulon and ivermectin.

Note: √ Nitroxynil is highly toxic to fish and aquatic invertebrates

How can it be administered?

A variety of application methods for administering pesticide products to cattle are in use.

√ Injectable

Resistance

Reported in:  √ Liver fluke

What is resistance?

Safety

• Harmful if swallowed. Avoid contact with eyes and skin and wash hands after use.

Everyone working in the rural industry has a ‘duty of care’; a legal obligation to provide a safe workplace for everyone on the property.

Withholding

• Always check the product label before use for specific withholding periods (WHP) and export slaughter interval (ESI) periods. Current ESI periods can be confirmed on the APVMA website.

Withholding periods are mandatory with all registered veterinary products used to treat animals for internal and external parasites.

Types of nitroxynil

A guide to the active nitroxynil and the pests it affects is in Table 1. See the ParaBoss Products Search Tool for the appropriate formulation and application method for your target pest. Note combinations and mixtures of actives may improve treatment efficacy.

Table 1. Nitroxynil, their active, combinations and mixtures and a summary of the targeted parasites for which formulations are registered for. Check marks indicate the pest targeted by multiple actives.

What is it?

Nitroxynil is a narrow-spectrum anthelmintic that was first introduced in the mid-1960s.

How does it work?

Nitroxynil disrupts the energy producing mitochondria within the parasites’ cells, impairing their mobility.